Presentation Detail

Population Genetics and/or Genomics, Theoretical

Furrow, Robert [1], Feldman, Marcus W. [2].

Epigenetic variation and the response to selection.

In a range of organisms, epigenetic variation appears to contribute to the heritability of ecologically relevant phenotypes. These observations suggest that epigenetic variation may allow a rapid evolutionary response to new selective pressures. However, it is not clear whether this variation is analogous to genetic variation. The mechanisms which produce high levels of epigenetic variation may also interfere with a sustained adaptive response to a novel stress. To explore this issue, we use a dynamic population genetic model of epigenetic transmission and mutation between generations. We find that epigenetic variation can allow a rapid adaptive response to a new selective pressure, but that the response is less sustained than that of a genetically variable population. Through simulations and mathematical analysis, we draw connections to classical results on the balance between genetic mutation and selection, demonstrating that the rates of epigenetic mutation critically determine the strength of an epigenetic response to selection. These results bring to light the importance of accurate measurements of the fidelity of epigenetic inheritance, and may help characterize the extent to which epigenetic variation can facilitate adaption.

1 - Stanford University, Biology, Gilbert Hall, 371 Serra Mall, Stanford, CA, 94305, USA
2 - Stanford University, Biology, Gilbert Hall, 371 Serra Mall, Stanford, CA, 94305, United States

Keywords:
Epigenetics
population genetics
Epigenetic inheritance
Mutation-selection balance
Response to selection.

Presentation Type: Regular Oral Presentation
Session: 17
Location: Alpine A and B/Snowbird Center
Date: Saturday, June 22nd, 2013
Time: 10:45 AM
Number: 17002
Abstract ID:116
Candidate for Awards:W.D. Hamilton Award for Outstanding Student Presentation