| Presentation Detail
Molecular Evolution Smukowski Heil, Caiti [1]. Past vs. Present: How well do LD-based linkage maps reflect present-day measures of recombination? Researchers have used linkage disequilibrium (LD) data to create fine scale historic recombination maps of humans, chimpanzees, and dogs. However, aside from sperm-typing studies in humans, few studies have compared historic LD-based estimates of recombination with those derived from direct counts of gamete or cross progeny genotypes. These two types of data may yield different estimates if recombination rates have evolved, which is likely since variation in recombination rates is well-known within and between many species. Further, application of LD-based approaches is not always feasible in other laboratory model organisms like Drosophila due to organismal constraints such as a high background recombination rate, high levels of nucleotide diversity, and frequency of adaptive substitutions. A new approach, implemented in the LDhelmet software package, addresses these concerns and may be applicable to a wider range of organisms. We compare the LD-estimated recombination maps, derived from 11 genome sequences of D. pseudoobscura, to recent empirical estimates of D. pseudobobscura recombination rate at multiple scales. Additionally, we examine the existence of recombination“hotspots” in Drosophila and associations of recombination rate with other genomic features.
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1 - Duke University, Biology, Box 90338 , Durham, NC, 27708, USA
Keywords:
Recombination
linkage disequilibrium
LDhelmet
LDhat.
Presentation Type: Regular Oral Presentation
Session: 125
Location: Alpine A and B/Snowbird Center
Date: Tuesday, June 25th, 2013
Time: 9:45 AM
Number: 125006
Abstract ID:386
Candidate for Awards:W.D. Hamilton Award for Outstanding Student Presentation |
